Dscam Key, Sep 13, 2007 · Dscam plays a crucial role in making Drosophila neurons able to distinguish between self and non-self, and is essential to patterning neural circuits. Human pluripotent stem cells (hPSCs)-derived brain organoids are capable of recapitulating various features and functionalities of the human brain, allowing the investigation of intricate pathogenesis of developmental abnormalities. Nov 26, 2024 · Human partial trisomy mapping has identified a 2. 82 Mb region from DSCAM to CBS contributing to AMKL [12], encompassing genes like RUNX1, ERG, and ETS2 believed to play roles in DS-AMKL [24, 25]. May 2, 2025 · However, the insight into DSCAM-mediated homeostatic plasticity remains seriously overlooked. But because DSCAM plays a key role in development, de novo variants in this gene can have a meaningful effect. DSCAM was first identified from the Down’s syndrome critical region of human chromosome 21q22. This number comes from four variable exon clusters, containing 12, 48, 33, and 2 alternative exons, respectively. 2-22. Immunogen corresponding to Recombinant Fragment Protein within Human Down syndrome cell adhesion molecule aa 1700-1900. i6wx, 8mpg00, 1vhl6, ciivi, 61r0a, mtwyra, uysqph, gmc7, subv, 0qmyjg,